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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOCK8 All Species: 8.79
Human Site: S49 Identified Species: 24.17
UniProt: Q8NF50 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8NF50 NP_982272.2 2099 238529 S49 I S T S G F P S L Q L P Q F Y
Chimpanzee Pan troglodytes XP_528526 2099 238441 S49 I S T S G F P S L Q L P Q F Y
Rhesus Macaque Macaca mulatta XP_001085641 2091 237677 H49 L E D Y L I T H P L A V D S G
Dog Lupus familis XP_533535 2033 231227 H49 E G V E L D P H V R D C V Q T
Cat Felis silvestris
Mouse Mus musculus Q8C147 2100 238960 S49 I S T S G F P S L Q L P Q L Y
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_424926 2034 231292 V54 D S H V R D C V Q T Y I R D W
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001920107 2136 242821 C99 Y N A S G S F C F N V P Q S Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608489 2064 234687 E51 P T E P L D Y E E F L S Q H M
Honey Bee Apis mellifera XP_394718 1977 220817 Q53 D Y E E F L A Q H Q S V L D R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 57.1 90.9 N.A. 91.9 N.A. N.A. N.A. 79.6 N.A. 65.8 N.A. 43.6 42.6 N.A. N.A.
Protein Similarity: 100 99.7 74.8 94 N.A. 95.7 N.A. N.A. N.A. 87.8 N.A. 80.2 N.A. 63.4 61.7 N.A. N.A.
P-Site Identity: 100 100 0 6.6 N.A. 93.3 N.A. N.A. N.A. 6.6 N.A. 33.3 N.A. 13.3 6.6 N.A. N.A.
P-Site Similarity: 100 100 6.6 20 N.A. 93.3 N.A. N.A. N.A. 20 N.A. 46.6 N.A. 20 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 0 0 0 12 0 0 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 12 12 0 0 0 12 0 0 0 % C
% Asp: 23 0 12 0 0 34 0 0 0 0 12 0 12 23 0 % D
% Glu: 12 12 23 23 0 0 0 12 12 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 12 34 12 0 12 12 0 0 0 23 0 % F
% Gly: 0 12 0 0 45 0 0 0 0 0 0 0 0 0 12 % G
% His: 0 0 12 0 0 0 0 23 12 0 0 0 0 12 0 % H
% Ile: 34 0 0 0 0 12 0 0 0 0 0 12 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 12 0 0 0 34 12 0 0 34 12 45 0 12 12 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % M
% Asn: 0 12 0 0 0 0 0 0 0 12 0 0 0 0 0 % N
% Pro: 12 0 0 12 0 0 45 0 12 0 0 45 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 12 12 45 0 0 56 12 0 % Q
% Arg: 0 0 0 0 12 0 0 0 0 12 0 0 12 0 12 % R
% Ser: 0 45 0 45 0 12 0 34 0 0 12 12 0 23 0 % S
% Thr: 0 12 34 0 0 0 12 0 0 12 0 0 0 0 12 % T
% Val: 0 0 12 12 0 0 0 12 12 0 12 23 12 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % W
% Tyr: 12 12 0 12 0 0 12 0 0 0 12 0 0 0 45 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _